Wednesday, 27 February 2013

Effect of l-Thyroxine on LDL and Total cholesterol in Hypothyroid patients

INTERNATIONAL  JOURNAL OF PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL SCIENCES

Available online at www.ijpcbs.com

Research Article

EFFECT OF THYROXINE ON LDL AND TOTAL CHOLESTEROL IN HYPOTHYROID PATIENTS
Nimmy. N. John*, MP. Narmadha and KM. Binu

1Nimmy N. John, Department of Pharmacy Practice, N.E.T Pharmacy College, Raichur, Karnataka, India.
2Narmadha M.P., Department of Pharmacy Practice, Swamy Vivekanandha College of pharmacy, Tiruchengode, Erode, India.
3Binu K.M, Department of Pharmacy Practice, N.E.T Pharmacy College, Raichur, Karnataka, India.
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ABSTRACT
The   study   was   carried   out   to   assess   the   effect   of   l-   thyroxine   on   low   density lipoprotein(LDL),  high density cholesterol(HDL)  and total cholesterol(TC)  in hypothyroid patients.  50 patients  who were newly diagnosed  with hypothyroidism  and on treatment with thyroxine was taken for the study. Patient’s demographic details, family history, symptoms    experienced    and   laboratory    investigation    of   TSH   (Thyroid    stimulating hormone),  T3 (Triiodothyroxine),  T4(Tetraiodothyronine) levels were collected  and this were analysed by descriptive statistics methods. The study reveals that in case of hypothyroidism   patients  having  age  group  below  45  years  an  increase  in  weight  and increase in cholesterol level is observed. It is also observed that lower limits of TSH during the course of treatment  and improvement  in T3 and T4 levels in hypothyroid  patients of the same age group. This detailed study of the investigations indicate that the normal level of TSH,T3,T4 and cholesterol level at the end of 3rd month and hence it can be concluded that the regular treatment  with l- thyroxine for a period of 1 year may help to attain the normal levels.

Key words: Hypothyroism, Thyroxine, Triiodothyroxine,  Tetraiodothyronine


INTRODUCTION
The   survey   of   case   study   reveals   that thyroid disorders are amongst the most common  endocrine  disorders  in India.  The prevalence   and   pattern   of   Thyroid

Incidence of Polypharmacy induced Drug interaction in a tertiary care hospital.

IJPSR (2012), Vol. 3, Issue 07         ISSN: 0975-8232


Available online on www.ijpsr.com  
                                                                                                                                 (Research Article)
Received on 28 March, 2012; received in revised form 07 May, 2012; accepted 16 June, 2012

INCIDENCE OF POLYPHARMACY INDUCED DRUG INTERACTION IN A TERTIARY CARE HOSPITAL
Nimmy N. John*, R.H. Udupi and K.M. Binu
Department of Pharmacy Practice, N.E.T. Pharmacy College, Raichur, Karnataka, India
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Keywords: Polypharmacy, Micromedex, Drug interaction, Co prescription
Correspondence to Author: Nimmy N. John
Department of Pharmacy Practice, N.E.T.
Pharmacy College, Raichur, Karnataka, India
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ABSTRACT
Drug interaction represents a major problem in day- to- day practice. The incidence of adverse reactions increases almost exponentially as the number of drugs co prescribed rises, and this is in part due to interaction. Critically ill, chronically ill and elderly patients are particularly at risk of drug interactions due  to  polypharmacy  as  well  as  impaired  homeostatic  mechanisms.  The study was aimed to assess polypharmacy and drug interaction in the prescriptions. The study was carried out by taking 200 prescriptions from different departments of our hospital and assessed the drug interaction through Micromedex and Drugs update. Polypharmacy was assessed using Prescribing indicators in WHO drug use indicators. Polypharmacy was observed in 85% of the prescriptions and drug interaction was observed in
58.5% of the prescriptions.


INTRODUCTION:
Drug interactions and side effects are the negative but real consequences of pharmacological therapy. The more medications patients take, the greater the potential for drug-drug interactions.